The recommended initial dose is 25 mg 1 time/day on days 1-21 of repeated 28-day cycles. Dexamethasone at a dose of 40 mg is prescribed 1 time/day in 1-4, 9-12 and 17-20 days of each 28-day cycle during the first 4 cycles of therapy, and then 40 mg 1 time/day in 1-4 days. each subsequent 28-day cycle.
With the development of toxic effects, the dosing regimen is adjusted according to a special scheme.
In patients with impaired renal function, a dosage regimen is required.